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Orphanin FQ/Nociceptin not only blocks but also reverses behavioral adaptive changes induced by repeated cocaine in mice
BACKGROUND: Orphanin FQ/Nociceptin (OFQ/N), the endogenous ligand of the opioid receptor-like (ORL1) receptor, blocks cocaine sensitization in rats. In the current study, we tested whether OFQ/N would block sensitization to the motor stimulatory and conditioned rewarding actions of cocaine in mice....
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2896563/ https://ncbi.nlm.nih.gov/pubmed/20359694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2010.02.010 |
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