Orphanin FQ/Nociceptin not only blocks but also reverses behavioral adaptive changes induced by repeated cocaine in mice

BACKGROUND: Orphanin FQ/Nociceptin (OFQ/N), the endogenous ligand of the opioid receptor-like (ORL1) receptor, blocks cocaine sensitization in rats. In the current study, we tested whether OFQ/N would block sensitization to the motor stimulatory and conditioned rewarding actions of cocaine in mice....

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Bibliografiske detaljer
Main Authors: Bebawy, David, Marquez, Paul, Samboul, Seroje, Parikh, Drupad, Hamid, Abdul, Lutfy, Kabirullah
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896563/
https://ncbi.nlm.nih.gov/pubmed/20359694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2010.02.010
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