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Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats

RATIONALE: Orphanin FQ/nociceptin (OFQ/N), the endogenous ligand of the opioid receptor-like (ORL-1) receptor, shows similarities to dynorphin A (1−17) in structure and functions. Dynorphin and other kappa opioid receptor agonists have been shown to block cocaine sensitization. OBJECTIVE: The presen...

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Detalhes bibliográficos
Main Authors: Lutfy, Kabirullah, Khaliq, Imran, Maidment, Nigel T., Carroll, F. Ivy
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268895/
https://ncbi.nlm.nih.gov/pubmed/12404079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-002-1192-1
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