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Blockade of μ-opioid receptors reveals the hyperalgesic effect of orphanin FQ/nociceptin in the rat hot plate test
1. Orphanin FQ (OFQ, also known as nociceptin) has been proposed to oppose the antinociceptive effect of endogenous opioid peptides in the brain. We sought to determine whether, conversely, the endogenous opioid peptides counteract a pronociceptive action of OFQ. 2. In testing this hypothesis, nalox...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2000
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1572505/ https://ncbi.nlm.nih.gov/pubmed/11139447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703746 |
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