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Phosphatidylinositol Containing Lipidic Particles Reduces Immunogenicity and Catabolism of Factor VIII in Hemophilia A Mice

Factor VIII (FVIII) is an important cofactor in blood coagulation cascade. It is a multidomain protein that consists of six domains, NH(2)-A1-A2-B-A3-C1-C2-COOH. The deficiency or dysfunction of FVIII causes hemophilia A, a life-threatening bleeding disorder. Replacement therapy using recombinant FV...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Peng, Aaron, Straubinger, Robert M., Balu-Iyer, Sathy V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer US 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895449/
https://ncbi.nlm.nih.gov/pubmed/20517659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-010-9207-z
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