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Down-regulation of CD40 signal and induction of TGF-β by Phosphatidylinositol mediates reduction in immunogenicity against recombinant human Factor VIII
Factor VIII (FVIII) is an important coagulation cofactor and its deficiency causes Hemophilia A, a bleeding disorder. Replacement therapy using recombinant FVIII is currently the first line of therapy for Hemophilia A, but the development of neutralizing antibody is a major clinical complication for...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3996553/ https://ncbi.nlm.nih.gov/pubmed/21953409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.22746 |
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