Down-regulation of CD40 signal and induction of TGF-β by Phosphatidylinositol mediates reduction in immunogenicity against recombinant human Factor VIII

Factor VIII (FVIII) is an important coagulation cofactor and its deficiency causes Hemophilia A, a bleeding disorder. Replacement therapy using recombinant FVIII is currently the first line of therapy for Hemophilia A, but the development of neutralizing antibody is a major clinical complication for...

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Hlavní autoři: Gaitonde, Puneet, Peng, Aaron, Straubinger, Robert M., Bankert, Richard B., Balu-Iyer, Sathy V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3996553/
https://ncbi.nlm.nih.gov/pubmed/21953409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.22746
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