An Oligomeric Equilibrium Intermediate as the Precursory Nucleus of Globular and Fibrillar Supramacromolecular Assemblies in a PDZ Domain

The equilibrium unfolding at neutral pH of the third PDZ domain of PSD95, as followed by DSC, is characterized by the presence of an equilibrium intermediate with clear signs of oligomerization. DLS and SEC measurements indicate that at 60–70°C small oligomers populate, showing a typical β-sheet far...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Murciano-Calles, Javier, Cobos, Eva S., Mateo, Pedro L., Camara-Artigas, Ana, Martinez, Jose C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Biophysical Society 2010
Ämnen:
Protein
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895384/
https://ncbi.nlm.nih.gov/pubmed/20655855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.04.003
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk