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Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are prototypic growth factors and receptor tyrosine kinases which have critical functions in development. We show that PDGFs share a conserved region in their prodomain sequences which can remain noncovalently associated with the m...

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Autori principali: Hye-Ryong Shim, Ann, Liu, Heli, Focia, Pamela J., Chen, Xiaoyan, Lin, P. Charles, He, Xiaolin
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895058/
https://ncbi.nlm.nih.gov/pubmed/20534510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000806107
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