Chargement en cours...
Structural basis for stem cell factor–KIT signaling and activation of class III receptor tyrosine kinases
Stem cell factor (SCF) binds to and activates the KIT receptor, a class III receptor tyrosine kinase (RTK), to stimulate diverse processes including melanogenesis, gametogenesis and hematopoeisis. Dysregulation of KIT activation is associated with many cancers. We report a 2.5 Å crystal structure of...
Enregistré dans:
| Auteurs principaux: | , , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2007
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1794399/ https://ncbi.nlm.nih.gov/pubmed/17255936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601545 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|