Structure of macrophage colony stimulating factor bound to FMS: Diverse signaling assemblies of class III receptor tyrosine kinases

Macrophage colony stimulating factor (M-CSF), through binding to its receptor FMS, a class III receptor tyrosine kinase (RTK), regulates the development and function of mononuclear phagocytes, and plays important roles in innate immunity, cancer and inflammation. We report a 2.4 Å crystal structure...

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Main Authors: Chen, Xiaoyan, Liu, Heli, Focia, Pamela J., Shim, Ann Hye-Ryong, He, Xiaolin
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2008
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587541/
https://ncbi.nlm.nih.gov/pubmed/19017797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807762105
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