Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages

Podosomes are integrin-containing adhesion structures commonly found in migrating leukocytes of the monocytic lineage. The actin cytoskeletal organisation of podosomes is based on a WASP- and Arp2/3-mediated mechanism. WASP also associates with a second protein, WIP (also known as WIPF1), and they c...

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Bibliographic Details
Published in:J Cell Sci
Main Authors: Vijayakumar, Vineetha, Monypenny, James, Chen, Xing Judy, Machesky, Laura M., Lilla, Sergio, Thrasher, Adrian J., Antón, Inés M., Calle, Yolanda, Jones, Gareth E.
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294773/
https://ncbi.nlm.nih.gov/pubmed/25413351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.154880
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