UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity

BACKGROUND: The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-induced thermogenesis. METHODOLOGY/PRINCIPAL FINDINGS: Here we report that cyclooxygenase (COX) activity and prostaglandin E(2) (PGE(2)) are crucially involved in induction of UCP1 expression...

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Bibliografski detalji
Glavni autori: Madsen, Lise, Pedersen, Lone M., Lillefosse, Haldis Haukaas, Fjære, Even, Bronstad, Ingeborg, Hao, Qin, Petersen, Rasmus K., Hallenborg, Philip, Ma, Tao, De Matteis, Rita, Araujo, Pedro, Mercader, Josep, Bonet, M. Luisa, Hansen, Jacob B., Cannon, Barbara, Nedergaard, Jan, Wang, Jun, Cinti, Saverio, Voshol, Peter, Døskeland, Stein Ove, Kristiansen, Karsten
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894971/
https://ncbi.nlm.nih.gov/pubmed/20613988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011391
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