UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity

BACKGROUND: The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-induced thermogenesis. METHODOLOGY/PRINCIPAL FINDINGS: Here we report that cyclooxygenase (COX) activity and prostaglandin E(2) (PGE(2)) are crucially involved in induction of UCP1 expression...

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Detalhes bibliográficos
Main Authors: Madsen, Lise, Pedersen, Lone M., Lillefosse, Haldis Haukaas, Fjære, Even, Bronstad, Ingeborg, Hao, Qin, Petersen, Rasmus K., Hallenborg, Philip, Ma, Tao, De Matteis, Rita, Araujo, Pedro, Mercader, Josep, Bonet, M. Luisa, Hansen, Jacob B., Cannon, Barbara, Nedergaard, Jan, Wang, Jun, Cinti, Saverio, Voshol, Peter, Døskeland, Stein Ove, Kristiansen, Karsten
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894971/
https://ncbi.nlm.nih.gov/pubmed/20613988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011391
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