Cyclic AMP (cAMP)-Mediated Stimulation of Adipocyte Differentiation Requires the Synergistic Action of Epac- and cAMP-Dependent Protein Kinase-Dependent Processes

Cyclic AMP (cAMP)-dependent processes are pivotal during the early stages of adipocyte differentiation. We show that exchange protein directly activated by cAMP (Epac), which functions as a guanine nucleotide exchange factor for the Ras-like GTPases Rap1 and Rap2, was required for cAMP-dependent sti...

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Main Authors: Petersen, Rasmus Koefoed, Madsen, Lise, Pedersen, Lone Møller, Hallenborg, Philip, Hagland, Hanne, Viste, Kristin, Døskeland, Stein Ove, Kristiansen, Karsten
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423297/
https://ncbi.nlm.nih.gov/pubmed/18391018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00709-07
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