A Gαi–GIV Molecular Complex Binds Epidermal Growth Factor Receptor and Determines Whether Cells Migrate or Proliferate

Cells respond to growth factors by either migrating or proliferating, but not both at the same time, a phenomenon termed migration-proliferation dichotomy. The underlying mechanism of this phenomenon has remained unknown. We demonstrate here that Gα(i) protein and GIV, its nonreceptor guanine nucleo...

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Detalhes bibliográficos
Main Authors: Ghosh, Pradipta, Beas, Anthony O., Bornheimer, Scott J., Garcia-Marcos, Mikel, Forry, Erin P., Johannson, Carola, Ear, Jason, Jung, Barbara H., Cabrera, Betty, Carethers, John M., Farquhar, Marilyn G.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893996/
https://ncbi.nlm.nih.gov/pubmed/20462955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-01-0028
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