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A Structural Determinant That Renders Gα(i) Sensitive to Activation by GIV/Girdin Is Required to Promote Cell Migration

Although several non-receptor activators of heterotrimeric G proteins have been identified, the structural features of G proteins that determine their interaction with such activators and the subsequent biological effects are poorly understood. Here we investigated the structural determinants in Gα(...

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Main Authors: Garcia-Marcos, Mikel, Ghosh, Pradipta, Ear, Jason, Farquhar, Marilyn G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857069/
https://ncbi.nlm.nih.gov/pubmed/20157114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.045161
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