Src Homology Domain 2-containing Protein-tyrosine Phosphatase-1 (SHP-1) Binds and Dephosphorylates Gα-interacting, Vesicle-associated Protein (GIV)/Girdin and Attenuates the GIV-Phosphatidylinositol 3-Kinase (PI3K)-Akt Signaling Pathway

GIV (Gα-interacting vesicle-associated protein, also known as Girdin) is a bona fide enhancer of PI3K-Akt signals during a diverse set of biological processes, e.g. wound healing, macrophage chemotaxis, tumor angiogenesis, and cancer invasion/metastasis. We recently demonstrated that tyrosine phosph...

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Bibliografiska uppgifter
Huvudupphovsmän: Mittal, Yash, Pavlova, Yelena, Garcia-Marcos, Mikel, Ghosh, Pradipta
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173146/
https://ncbi.nlm.nih.gov/pubmed/21799016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.275685
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