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Molecular-Targeted Antitumor Agents 19: Furospongolide from a Marine Lendenfeldia sp. Sponge Inhibits Hypoxia-Inducible Factor-1 (HIF-1) Activation in Breast Tumor Cells

[Image: see text] A natural product chemistry-based approach was employed to discover small molecule inhibitors of the important tumor-selective molecular target hypoxia-inducible factor-1 (HIF-1). Bioassay-guided isolation of an active lipid extract of a Saipan collection of the marine sponge Lende...

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Autors principals: Liu, Yang, Liu, Rui, Mao, Shui-Chun, Morgan, J. Brian, Jekabsons, Mika B., Zhou, Yu-Dong, Nagle, Dale G.
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893247/
https://ncbi.nlm.nih.gov/pubmed/18989978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np800342s
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