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Lipophilic 2,5-Disubstituted Pyrroles from the Marine Sponge Mycale sp. Inhibit Mitochondrial Respiration and HIF-1 Activation

The lipid extract of the marine sponge Mycale sp. inhibited the activation of hypoxiainducible factor-1 (HIF-1) in a human breast tumor T47D cell-based reporter assay. Bioassay-guided isolation and structure elucidation yielded 18 new lipophilic 2,5-disubstituted pyrroles, and eight structurally rel...

詳細記述

保存先:
書誌詳細
主要な著者: Mao, Shui-Chun, Liu, Yang, Morgan, J. Brian, Jekabsons, Mika B., Zhou, Yu-Dong, Nagle, Dale G.
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868385/
https://ncbi.nlm.nih.gov/pubmed/19845338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np900444m
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