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The Caulerpa Pigment Caulerpin Inhibits HIF-1 Activation and Mitochondrial Respiration
The transcription factor hypoxia-inducible factor-1 (HIF-1) represents an important molecular target for anticancer drug discovery. In a T47D cell-based reporter assay, the Caulerpa spp. algal pigment caulerpin (1) inhibited hypoxia-induced as well as 1,10-phenanthroline-induced HIF-1 activation. Th...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2798910/ https://ncbi.nlm.nih.gov/pubmed/19921787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np9005794 |
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