The Caulerpa Pigment Caulerpin Inhibits HIF-1 Activation and Mitochondrial Respiration

The transcription factor hypoxia-inducible factor-1 (HIF-1) represents an important molecular target for anticancer drug discovery. In a T47D cell-based reporter assay, the Caulerpa spp. algal pigment caulerpin (1) inhibited hypoxia-induced as well as 1,10-phenanthroline-induced HIF-1 activation. Th...

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Autores principales: Liu, Yang, Morgan, J. Brian, Coothankandaswamy, Veena, Liu, Rui, Jekabsons, Mika B., Mahdi, Fakhri, Nagle, Dale G., Zhou, Yu-Dong
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798910/
https://ncbi.nlm.nih.gov/pubmed/19921787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np9005794
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