VX680/MK-0457, a potent and selective Aurora kinase inhibitor, targets both tumor and endothelial cells in clear cell renal cell carcinoma

Aurora kinases are key regulators of cell mitosis and have been implicated in the process of tumorigenesis. In recent years, the Aurora kinases have attracted much interest as promising targets for cancer treatment. Here we report on the roles of Aurora A and Aurora B kinases in clear cell renal cel...

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Autors principals: Li, Yan, Zhang, Zhong-Fa, Chen, Jindong, Huang, Dan, Ding, Yan, Tan, Min-Han, Qian, Chao-Nan, Resau, James H, Kim, Hyung, Teh, Bin Tean
Format: Artigo
Idioma:Inglês
Publicat: e-Century Publishing Corporation 2010
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892409/
https://ncbi.nlm.nih.gov/pubmed/20589168
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