Co-treatment with vorinostat enhances activity of MK-0457 (VX-680) against acute and chronic myelogenous leukemia cells

PURPOSE: We determined the effects of vorinostat [suberoylanalide hydroxamic acid (SAHA)] and/or MK-0457 (VX-680), an Aurora kinase inhibitor on the cultured human (HL-60, OCI-AML3 and K562) and primary acute (AML) and chronic myelogenous leukemia (CML), as well as on the murine pro-B BaF3 cells wit...

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Detalhes bibliográficos
Main Authors: Fiskus, Warren, Wang, Yongchao, Joshi, Rajeshree, Rao, Rekha, Yang, Yonghua, Chen, Jianguang, Kolhe, Ravindra, Balusu, Ramesh, Eaton, Kelly, Lee, Pearl, Ustun, Celalettin, Jillella, Anand, Buser, Carolyn A., Peiper, Stephen, Bhalla, Kapil
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665710/
https://ncbi.nlm.nih.gov/pubmed/18829489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0721
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