Targeting Aurora Kinase with MK-0457 Inhibits Ovarian Cancer Growth

PURPOSE: The Aurora kinase family plays pivotal roles in mitotic integrity and cell cycle.We sought to determine the effects of inhibiting Aurora kinase on ovarian cancer growth in an orthotopic mouse model using a small molecule pan-Aurora kinase inhibitor, MK-0457. EXPERIMENTAL DESIGN: We examined...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lin, Yvonne G., Immaneni, Anand, Merritt, William M., Mangala, Lingegowda S., Kim, SeungWook, Shahzad, Mian M.K., Tsang, Yvonne T.M., Armaiz-Pena, Guillermo N., Lu, Chunhua, Kamat, Aparna A., Han, Liz Y., Spannuth, WhitneyA., Nick, Alpa M., Landen, Charles N., Wong, Kwong K., Gray, Michael J., Coleman, Robert L., Bodurka, Diane C., Brinkley, William R., Sood, Anil K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766914/
https://ncbi.nlm.nih.gov/pubmed/18765535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-4922
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