Targeting Aurora Kinase with MK-0457 Inhibits Ovarian Cancer Growth

PURPOSE: The Aurora kinase family plays pivotal roles in mitotic integrity and cell cycle.We sought to determine the effects of inhibiting Aurora kinase on ovarian cancer growth in an orthotopic mouse model using a small molecule pan-Aurora kinase inhibitor, MK-0457. EXPERIMENTAL DESIGN: We examined...

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主要な著者: Lin, Yvonne G., Immaneni, Anand, Merritt, William M., Mangala, Lingegowda S., Kim, SeungWook, Shahzad, Mian M.K., Tsang, Yvonne T.M., Armaiz-Pena, Guillermo N., Lu, Chunhua, Kamat, Aparna A., Han, Liz Y., Spannuth, WhitneyA., Nick, Alpa M., Landen, Charles N., Wong, Kwong K., Gray, Michael J., Coleman, Robert L., Bodurka, Diane C., Brinkley, William R., Sood, Anil K.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766914/
https://ncbi.nlm.nih.gov/pubmed/18765535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-4922
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