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Targeting Aurora Kinase with MK-0457 Inhibits Ovarian Cancer Growth

PURPOSE: The Aurora kinase family plays pivotal roles in mitotic integrity and cell cycle.We sought to determine the effects of inhibiting Aurora kinase on ovarian cancer growth in an orthotopic mouse model using a small molecule pan-Aurora kinase inhibitor, MK-0457. EXPERIMENTAL DESIGN: We examined...

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Detalhes bibliográficos
Main Authors: Lin, Yvonne G., Immaneni, Anand, Merritt, William M., Mangala, Lingegowda S., Kim, SeungWook, Shahzad, Mian M.K., Tsang, Yvonne T.M., Armaiz-Pena, Guillermo N., Lu, Chunhua, Kamat, Aparna A., Han, Liz Y., Spannuth, WhitneyA., Nick, Alpa M., Landen, Charles N., Wong, Kwong K., Gray, Michael J., Coleman, Robert L., Bodurka, Diane C., Brinkley, William R., Sood, Anil K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766914/
https://ncbi.nlm.nih.gov/pubmed/18765535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-4922
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