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Paternal versus maternal transmission of a stimulatory G-protein α subunit knockout produces opposite effects on energy metabolism
Heterozygous disruption of Gnas, the gene encoding the stimulatory G-protein α subunit (G(s)α), leads to distinct phenotypes depending on whether the maternal (m–/+) or paternal (+/p–) allele is disrupted. G(s)α is imprinted, with the maternal allele preferentially expressed in adipose tissue. Hence...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC289181/ https://ncbi.nlm.nih.gov/pubmed/10712433 |
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