Paternal versus maternal transmission of a stimulatory G-protein α subunit knockout produces opposite effects on energy metabolism

Heterozygous disruption of Gnas, the gene encoding the stimulatory G-protein α subunit (G(s)α), leads to distinct phenotypes depending on whether the maternal (m–/+) or paternal (+/p–) allele is disrupted. G(s)α is imprinted, with the maternal allele preferentially expressed in adipose tissue. Hence...

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Main Authors: Yu, Shuhua, Gavrilova, Oksana, Chen, Hui, Lee, Randy, Liu, Jie, Pacak, Karel, Parlow, A.F., Quon, Michael J., Reitman, Marc L., Weinstein, Lee S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2000
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC289181/
https://ncbi.nlm.nih.gov/pubmed/10712433
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