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Severe Obesity and Insulin Resistance due to Deletion of the Maternal G(s)α Allele Is Reversed by Paternal Deletion of the G(s)α Imprint Control Region
The G protein α-subunit G(s)α mediates receptor-stimulated cAMP production and is imprinted with reduced expression from the paternal allele in specific tissues. Disruption of the G(s)α maternal (but not paternal) allele leads to severe obesity, hypertriglyceridemia, and insulin resistance in mice a...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Endocrine Society
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2329281/ https://ncbi.nlm.nih.gov/pubmed/18202131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-1458 |
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