Severe Obesity and Insulin Resistance due to Deletion of the Maternal G(s)α Allele Is Reversed by Paternal Deletion of the G(s)α Imprint Control Region

The G protein α-subunit G(s)α mediates receptor-stimulated cAMP production and is imprinted with reduced expression from the paternal allele in specific tissues. Disruption of the G(s)α maternal (but not paternal) allele leads to severe obesity, hypertriglyceridemia, and insulin resistance in mice a...

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Bibliographic Details
Main Authors: Xie, Tao, Chen, Min, Gavrilova, Oksana, Lai, Edwin W., Liu, Jie, Weinstein, Lee S.
Format: Artigo
Language:Inglês
Published: The Endocrine Society 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2329281/
https://ncbi.nlm.nih.gov/pubmed/18202131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-1458
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