Variable and tissue-specific hormone resistance in heterotrimeric G(s) protein α-subunit (G(s)α) knockout mice is due to tissue-specific imprinting of the G(s)α gene

Albright hereditary osteodystrophy (AHO), an autosomal dominant disorder characterized by short stature, obesity, and skeletal defects, is associated with heterozygous inactivating mutations of GNAS1, the gene encoding the heterotrimeric G protein α-subunit (G(s)α) that couples multiple receptors to...

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Bibliografske podrobnosti
Main Authors: Yu, Shuhua, Yu, Dawen, Lee, Eric, Eckhaus, Michael, Lee, Randy, Corria, Zakia, Accili, Domenico, Westphal, Heiner, Weinstein, Lee S.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 1998
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC21142/
https://ncbi.nlm.nih.gov/pubmed/9671744
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