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Halogenated β,γ-methylene- and ethylidene-dGTP-DNA ternary complexes with DNA polymerase β: structural evidence for stereospecific binding of the fluoromethylene analogues

β,γ-Fluoromethylene analogues of nucleotides are considered to be useful mimics of the natural substrates, but direct structural evidence defining their active site interactions has not been available, including the influence of the new chiral center introduced at the CHF carbon, as in β,γ-fluoromet...

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Detaylı Bibliyografya
Asıl Yazarlar: Batra, Vinod K., Pedersen, Lars C., Beard, William A., Wilson, Samuel H., Kashemirov, Boris A., Upton, Thomas G., Goodman, Myron F., McKenna, Charles E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891752/
https://ncbi.nlm.nih.gov/pubmed/20465217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja909370k
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