Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts

Osteoclasts express the αvβ3 integrin, an adhesion receptor that has been implicated in bone resorption and that is therefore a potential therapeutic target. To assess the role of this heterodimer in skeletal development in vivo, we engineered mice in which the gene for the β3 integrin subunit was d...

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Pubblicato in:	J Clin Invest
Autori principali:	McHugh, Kevin P., Hodivala-Dilke, Kairbaan, Zheng, Ming-Hao, Namba, Noriyuki, Lam, Jonathan, Novack, Deborah, Feng, Xu, Ross, F. Patrick, Hynes, Richard O., Teitelbaum, Steven L.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 2000
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC289172/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10683372/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8905
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