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Imatinib blocks migration and invasion of medulloblastoma cells by concurrently inhibiting activation of PDGFR and transactivation of EGFR
Platelet-derived growth factor receptor (PDGFR) expression correlates with metastatic medulloblastoma. PDGF stimulation of medulloblastoma cells phosphorylates Erk and promotes migration. We sought to determine whether blocking PDGFR activity effectively inhibits signaling required for medulloblasto...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2891380/ https://ncbi.nlm.nih.gov/pubmed/19417143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0889 |
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