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Mitochondrial DNA deletions in Mice in Men: substantia nigra is much less affected in the mouse

Mitochondrial DNA (mtDNA) deletions have been reported to accumulate to high levels in substantia nigra of older humans, and these mutations are suspected of causing age-related degeneration in this area. We have compared levels of mtDNA deletions in humans and mice and report here that levels of de...

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Detalhes bibliográficos
Main Authors: Guo, Xinhong, Kudryavtseva, Elena, Bodyak, Natalya, Nicholas, Alexander, Dombrovsky, Igor, Yang, Deye, Kraytsberg, Yevgenya, Simon, David K., Khrapko, Konstantin
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891141/
https://ncbi.nlm.nih.gov/pubmed/20388490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbabio.2010.04.005
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