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Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli
Hepcidin, a key regulator of iron metabolism, is a small antimicrobial peptide produced by the liver that regulates intestinal iron absorption and iron recycling by macrophages. Hepcidin is stimulated when iron stores increase and during inflammation and, conversely, is inhibited by hypoxia and augm...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2891008/ https://ncbi.nlm.nih.gov/pubmed/19204324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-173641 |
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