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Iron overload inhibits BMP/SMAD and IL-6/STAT3 signaling to hepcidin in cultured hepatocytes

Hepcidin is a peptide hormone that targets the iron exporter ferroportin, thereby limiting iron entry into the bloodstream. It is generated in hepatocytes mainly in response to increased body iron stores or inflammatory cues. Iron stimulates expression of bone morphogenetic protein 6 (BMP6) from liv...

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Veröffentlicht in:PLoS One
Hauptverfasser: Charlebois, Edouard, Pantopoulos, Kostas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221488/
https://ncbi.nlm.nih.gov/pubmed/34161397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0253475
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