Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload

The inhibitory Smad7 acts as a critical suppressor of hepcidin, the major regulator of systemic iron homeostasis. In this study we define the mRNA expression of the two functionally related Smad proteins, Smad6 and Smad7, within pathways known to regulate hepcidin levels. Using mouse models for here...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Spasić, Maja Vujić, Sparla, Richard, Mleczko-Sanecka, Katarzyna, Migas, Mary C., Breitkopf-Heinlein, Katja, Dooley, Steven, Vaulont, Sophie, Fleming, Robert E., Muckenthaler, Martina U.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7731909/
https://ncbi.nlm.nih.gov/pubmed/22960056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2012.08.013
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