Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in T(H)17 differentiation

Transforming growth factor-β (TGF-β) and interleukin-6 (IL-6) are the pivotal cytokines to induce IL-17-producing CD4(+) T helper cells (T(H)17); yet their signalling network remains largely unknown. Here we show that the highly homologous TGF-β receptor-regulated Smads (R-Smads): Smad2 and Smad3 op...

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發表在:Nat Commun
Main Authors: Yoon, Jeong-Hwan, Sudo, Katsuko, Kuroda, Masahiko, Kato, Mitsuyasu, Lee, In-Kyu, Han, Jin Soo, Nakae, Susumu, Imamura, Takeshi, Kim, Juryun, Ju, Ji Hyeon, Kim, Dae-Kee, Matsuzaki, Koichi, Weinstein, Michael, Matsumoto, Isao, Sumida, Takayuki, Mamura, Mizuko
格式: Artigo
語言:Inglês
出版: Nature Pub. Group 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518312/
https://ncbi.nlm.nih.gov/pubmed/26194464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8600
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