Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in T(H)17 differentiation

Transforming growth factor-β (TGF-β) and interleukin-6 (IL-6) are the pivotal cytokines to induce IL-17-producing CD4(+) T helper cells (T(H)17); yet their signalling network remains largely unknown. Here we show that the highly homologous TGF-β receptor-regulated Smads (R-Smads): Smad2 and Smad3 op...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Nat Commun
Autores principales: Yoon, Jeong-Hwan, Sudo, Katsuko, Kuroda, Masahiko, Kato, Mitsuyasu, Lee, In-Kyu, Han, Jin Soo, Nakae, Susumu, Imamura, Takeshi, Kim, Juryun, Ju, Ji Hyeon, Kim, Dae-Kee, Matsuzaki, Koichi, Weinstein, Michael, Matsumoto, Isao, Sumida, Takayuki, Mamura, Mizuko
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518312/
https://ncbi.nlm.nih.gov/pubmed/26194464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8600
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares