Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions

Transforming growth factor-β (TGF-β) is involved in vascular formation through activin receptor-like kinase (ALK)1 and ALK5. ALK5, which is expressed ubiquitously, phosphorylates Smad2 and Smad3, whereas endothelial cell (EC)–specific ALK1 activates Smad1 and Smad5. Because ALK5 kinase activity is r...

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Detalhes bibliográficos
Main Authors: Itoh, Fumiko, Itoh, Susumu, Adachi, Tomomi, Ichikawa, Kei, Matsumura, Yutaka, Takagi, Takahiro, Festing, Maria, Watanabe, Takuya, Weinstein, Michael, Karlsson, Stefan, Kato, Mitsuyasu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628112/
https://ncbi.nlm.nih.gov/pubmed/22498737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-395772
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