Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions

Transforming growth factor-β (TGF-β) is involved in vascular formation through activin receptor-like kinase (ALK)1 and ALK5. ALK5, which is expressed ubiquitously, phosphorylates Smad2 and Smad3, whereas endothelial cell (EC)–specific ALK1 activates Smad1 and Smad5. Because ALK5 kinase activity is r...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Itoh, Fumiko, Itoh, Susumu, Adachi, Tomomi, Ichikawa, Kei, Matsumura, Yutaka, Takagi, Takahiro, Festing, Maria, Watanabe, Takuya, Weinstein, Michael, Karlsson, Stefan, Kato, Mitsuyasu
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2012
Gaiak:
Vascular Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628112/
https://ncbi.nlm.nih.gov/pubmed/22498737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-395772
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