Smad7 and protein phosphatase 1α are critical determinants in the duration of TGF-β/ALK1 signaling in endothelial cells

BACKGROUND: In endothelial cells (EC), transforming growth factor-β (TGF-β) can bind to and transduce signals through ALK1 and ALK5. The TGF-β/ALK5 and TGF-β/ALK1 pathways have opposite effects on EC behaviour. Besides differential receptor binding, the duration of TGF-β signaling is an important sp...

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Main Authors: Valdimarsdottir, Gudrun, Goumans, Marie-José, Itoh, Fumiko, Itoh, Susumu, Heldin, Carl-Henrik, Dijke, Peter ten
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2006
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479810/
https://ncbi.nlm.nih.gov/pubmed/16571110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-7-16
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