Hematopoietic stem cell function requires 12/15-lipoxygenase–dependent fatty acid metabolism

Fatty acid metabolism governs multiple intracellular signaling pathways in many cell types, but its role in hematopoietic stem cells (HSCs) is largely unknown. Herein, we establish a critical role for 12/15-lipoxygenase (12/15-LOX)–mediated unsaturated fatty acid metabolism in HSC function. HSCs fro...

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Bibliographic Details
Main Authors: Kinder, Michelle, Wei, Cong, Shelat, Suresh G., Kundu, Mondira, Zhao, Liang, Blair, Ian A., Puré, Ellen
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2010
Subjects:
Hematopoiesis and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890149/
https://ncbi.nlm.nih.gov/pubmed/20357242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-09-243139
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