AAV Vectors Avoid Inflammatory Signals Necessary to Render Transduced Hepatocyte Targets for Destructive T Cells

Studies in mice indicate that gene transfer to liver with vectors based on adeno-associated viruses (AAVs) is characterized by immunological tolerance to antigenic transgene products. Mechanisms to explain host nonresponsiveness have focused on aberrant T-cell responses. We propose a distinct mechan...

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Bibliographic Details
Main Authors: Somanathan, Suryanarayan, Breous, Ekaterina, Bell, Peter, Wilson, James M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2010
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890110/
https://ncbi.nlm.nih.gov/pubmed/20234342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.40
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