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Inflammation Causes Loss of Adeno-Associated Virus-Mediated Transgene Expression in Mouse Liver
BACKGROUND & AIMS: Transgenes delivered to livers of mice via adeno-associated virus (AAV) are expressed stably, via induction of immune tolerance. However, transgene expression is lost in higher-order primates. We investigated whether inflammatory processes, which likely differ between species,...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3269906/ https://ncbi.nlm.nih.gov/pubmed/21640112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.04.002 |
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