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A single base deletion in the 5' noncoding region of Theiler's virus attenuates neurovirulence.

Viral chimeras have been constructed through in vitro manipulations of the infectious cDNA clones of two prototypes of Theiler's murine encephalomyelitis virus: (i) the virulent GDVII strain and (ii) the less virulent BeAn and VL strains. Previous studies have suggested that the phenotypic diff...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Pritchard, A E, Calenoff, M A, Simpson, S, Jensen, K, Lipton, H L
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1992
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288983/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1548749/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.4.1951-1958.1992
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