A single base deletion in the 5' noncoding region of Theiler's virus attenuates neurovirulence.

Viral chimeras have been constructed through in vitro manipulations of the infectious cDNA clones of two prototypes of Theiler's murine encephalomyelitis virus: (i) the virulent GDVII strain and (ii) the less virulent BeAn and VL strains. Previous studies have suggested that the phenotypic differenc...

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Pubblicato in:	J Virol
Autori principali:	Pritchard, A E, Calenoff, M A, Simpson, S, Jensen, K, Lipton, H L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288983/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1548749/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.4.1951-1958.1992
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