A single base deletion in the 5' noncoding region of Theiler's virus attenuates neurovirulence.

Viral chimeras have been constructed through in vitro manipulations of the infectious cDNA clones of two prototypes of Theiler's murine encephalomyelitis virus: (i) the virulent GDVII strain and (ii) the less virulent BeAn and VL strains. Previous studies have suggested that the phenotypic differenc...

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Detalles Bibliográficos

Publicado en:	J Virol
Autores principales:	Pritchard, A E, Calenoff, M A, Simpson, S, Jensen, K, Lipton, H L
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1992
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288983/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1548749/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.4.1951-1958.1992
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