A single base deletion in the 5' noncoding region of Theiler's virus attenuates neurovirulence.

Viral chimeras have been constructed through in vitro manipulations of the infectious cDNA clones of two prototypes of Theiler's murine encephalomyelitis virus: (i) the virulent GDVII strain and (ii) the less virulent BeAn and VL strains. Previous studies have suggested that the phenotypic differenc...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Pritchard, A E, Calenoff, M A, Simpson, S, Jensen, K, Lipton, H L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288983/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1548749/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.4.1951-1958.1992
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