A single base deletion in the 5' noncoding region of Theiler's virus attenuates neurovirulence.

Viral chimeras have been constructed through in vitro manipulations of the infectious cDNA clones of two prototypes of Theiler's murine encephalomyelitis virus: (i) the virulent GDVII strain and (ii) the less virulent BeAn and VL strains. Previous studies have suggested that the phenotypic differenc...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Pritchard, A E, Calenoff, M A, Simpson, S, Jensen, K, Lipton, H L
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1992
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288983/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1548749/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.4.1951-1958.1992
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