The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2.

Interferon resistance of vaccinia virus is mediated by specific inhibition of phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF-2 alpha) by the double-stranded-RNA-activated (DAI) protein kinase. Vaccinia virus encodes a homolog of eIF-2 alpha, K3L, the deletion of which re...

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Dettagli Bibliografici

Pubblicato in:	J Virol
Autori principali:	Davies, M V, Elroy-Stein, O, Jagus, R, Moss, B, Kaufman, R J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288982/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1347793/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.4.1943-1950.1992
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