The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2.

Interferon resistance of vaccinia virus is mediated by specific inhibition of phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF-2 alpha) by the double-stranded-RNA-activated (DAI) protein kinase. Vaccinia virus encodes a homolog of eIF-2 alpha, K3L, the deletion of which re...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Davies, M V, Elroy-Stein, O, Jagus, R, Moss, B, Kaufman, R J
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288982/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1347793/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.4.1943-1950.1992
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