The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2.

Interferon resistance of vaccinia virus is mediated by specific inhibition of phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF-2 alpha) by the double-stranded-RNA-activated (DAI) protein kinase. Vaccinia virus encodes a homolog of eIF-2 alpha, K3L, the deletion of which re...

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書誌詳細
出版年:	J Virol
主要な著者:	Davies, M V, Elroy-Stein, O, Jagus, R, Moss, B, Kaufman, R J
フォーマット:	Artigo
言語:	Inglês
出版事項:	American Society for Microbiology (ASM) 1992
主題:	Research Article
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288982/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1347793/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.4.1943-1950.1992
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The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2.

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