The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2.

Interferon resistance of vaccinia virus is mediated by specific inhibition of phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF-2 alpha) by the double-stranded-RNA-activated (DAI) protein kinase. Vaccinia virus encodes a homolog of eIF-2 alpha, K3L, the deletion of which re...

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Εκδόθηκε σε:	J Virol
Κύριοι συγγραφείς:	Davies, M V, Elroy-Stein, O, Jagus, R, Moss, B, Kaufman, R J
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology (ASM) 1992
Θέματα:	Research Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288982/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1347793/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.4.1943-1950.1992
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