A High-throughput Pharmacoviral Approach Identifies Novel Oncolytic Virus Sensitizers

Oncolytic viruses (OVs) are promising anticancer agents but like other cancer monotherapies, the genetic heterogeneity of human malignancies can lead to treatment resistance. We used a virus/cell-based assay to screen diverse chemical libraries to identify small molecules that could act in synergy w...

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Autors principals: Diallo, Jean-Simon, Boeuf, Fabrice Le, Lai, Frances, Cox, Julie, Vaha-Koskela, Markus, Abdelbary, Hesham, MacTavish, Heather, Waite, Katherine, Falls, Theresa, Wang, Jenny, Brown, Ryan, Blanchard, Jan E, Brown, Eric D, Kirn, David H, Hiscott, John, Atkins, Harry, Lichty, Brian D, Bell, John C
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889739/
https://ncbi.nlm.nih.gov/pubmed/20389287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.67
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