A High-throughput Pharmacoviral Approach Identifies Novel Oncolytic Virus Sensitizers

Oncolytic viruses (OVs) are promising anticancer agents but like other cancer monotherapies, the genetic heterogeneity of human malignancies can lead to treatment resistance. We used a virus/cell-based assay to screen diverse chemical libraries to identify small molecules that could act in synergy w...

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Bibliografiska uppgifter
Huvudupphovsmän: Diallo, Jean-Simon, Boeuf, Fabrice Le, Lai, Frances, Cox, Julie, Vaha-Koskela, Markus, Abdelbary, Hesham, MacTavish, Heather, Waite, Katherine, Falls, Theresa, Wang, Jenny, Brown, Ryan, Blanchard, Jan E, Brown, Eric D, Kirn, David H, Hiscott, John, Atkins, Harry, Lichty, Brian D, Bell, John C
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2010
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Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889739/
https://ncbi.nlm.nih.gov/pubmed/20389287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.67
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